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Re: Novel Antidepressants in the Pipeline

Posted by SLS on June 29, 2023, at 20:53:10

In reply to Re: Novel Antidepressants in the Pipeline, posted by Hugh on June 29, 2023, at 19:23:42

Hi, Hugh.


> One novel treatment for depression I will add to this is H2 (hydrogen) therapy -- both hydrogen inhalation and by drinking hydrogen-rich water.
>
> https://nulifesciences.com/the-science/effects-of-hydrogen-water-on-depression/
>
> https://www.mdpi.com/2076-3921/11/11/2153
>
> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731988/
>
> I ordered a machine from Amazon that produces both hydrogen for inhalation and hydrogen-rich water. It produces hydrogen from a small amount of distilled water that only has to be replaced after about 20 hours of use. The machine costs $559. It's a portable model that produces 150 ml of hydrogen per minute. Machines that produce 300 ml per minute cost about twice as much. It's arriving tomorrow. At some point in the future, I will post about my experiences with hydrogen.
>
> Tablets that produce hydrogen-rich water are available online. I haven't tried these.


I can't believe the stuff you come up with. It was the information you provided regarding psilocybin that persuaded me to make it my first choice should I relapse. I would leave all of my meds in place and take a series of doses of psilocybin. I would hope that this would promote enough neuroplasticity to allow the brain to break free of some sort of sticking point.

This is all an abstraction, of course.

Do you think microdoses of psilocybin are as effective as psychedelic dosages? How often would you take microdoses? Once a day? Once a week?

I don't think there is an untoward interaction between a MAOI and psilocybin. I'll have to remember where I read that.

I appreciate your dropping in.

It gets lonely when you chase all of your friends away with a manic / hypomanic episode. A few months ago, I suffered a horrendous episode of pain due to lumbar spinal stenosis. I couldn't walk without screaming. So, I screamed. I was prescribed prendisone. Then, I was put on meloxicam (Mobic), a NSAID. Fortunately, my pharmacist told me that meloxicam interacts with lithium to increase blood levels of lithium. I started to become toxic. It was a real mess.

One week of mania can destroy a life more completely than months or years of depression. Believe it.

It was my intention to post without any social interaction just to provide information for anyone who might visit the board.

I will take a look at your citations. Thank you, Hugh.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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poster:SLS thread:1122108
URL: http://www.dr-bob.org/babble/20230117/msgs/1122114.html