Posted by undopaminergic on December 31, 2022, at 14:03:45
In reply to Re: Tentative remission on ketamine, posted by Jay2112 on December 30, 2022, at 15:37:31
> Interesting....there is some new research discussing how the dissociative affects of ketamine, which bring it's therapeutic effects, as well as THC, are those we find in Scizophrenia. I find that too, with mid-dose THC, I get a fairly high dissociative feeling going. Dissociation is not always figured with Scizophrenia, but new studies are showing different: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964156/
>
> I'd take a stab at possible high dopamine levels with something like high GABA levels as well, play a part in this. The serotonin and GABA, along with norepinephrine and dopamine, are said to be increased much by Nardil, in particular, GABA.
>
> JayIn my view, NMDA-glutamatergic receptor antagonists, like ketamine or memantine, enhance the *functional* dopaminergic tone, without necessarily elevating dopamine concentrations at all. They achieve stimulant-like or even manic-like effects by a mechanism of action that is distinct from the way stimulants like cocaine or Ritalin do.
-undopaminergic
poster:undopaminergic
thread:1121402
URL: http://www.dr-bob.org/babble/20220917/msgs/1121432.html