Re: 120mg of fluoxetine

> I've been on 80 for about couple years. They have used 120mg for treatment resistant depression, I really want to go to 120, i've taken it before and yes it has a bit more stronger antidepressant effect, not much but you can notice. Medical maximum dosage is 80. I need to find a shrink that will allow 120, because it does have good antidepressant effects at that dose. Prozac i've read is lesser effective than other SSRI's. 1 because it takes 6 weeks or more to work, it's not as potent because it's the 'least' selective on serotonin sites. But if the dose was bumped up it may have more potent effects

Anything that works for you is potent enough, whether it is 37.5 mg of Effexor or 120 mg/day of Prozac.

You never know what you will eventually arrive at that turns the switch on. I had success reviewing which drugs helped and which didn't. In moving forward with drug trials, I ended up choosing drugs with little regard to the minutia of psychopharmacology. I am not taking away anything from your study and research of the brain and how various compounds affect it. However, when it comes to the brain - and medicine in general - the empirical is sometimes more important than the theoretical. For people like us, thinking outside the box is critical. If your pursuit of a cure is based solely on what neuroscience says today, consider what neuroscience said 20-40 years ago. If you were to rely solely on the norepinephrine theory of depression in 1980, where would that get you today? I brought in dopamine to my doctors at Columbia and asked them for Wellbutrin. My dopamine hypothesis and desire to try bromocriptine earned me laughter by Wilma Harrison, who later sought out to prove that vitamin-B6 could cure premenstrual "tension". She ended up on the team to get sertraline to market. In the mid-1980s came serotonin. When Prozac came out, I had already been on 3 novel serotoninergic drugs from France. With the marketing of Prozac came the loss of norepinephrine from memory overnight. How many compounds have been synthesized since then? How many receptors and sub-receptors have been discovered since? Of course, one day, this will all be figured out, but perhaps not in your lifetime. This understanding must incorporated an explanation for the interindividual heterogeneity of people's divergent responses to the same drug. I imagine somewhere there exists a Venn diagram for how to combine the use theoretical possibilities with life-charting one's factual history of treatments and their results.

All of the four drugs that I benefit from were available to be combined in 1996. I was only 36 then. That's a bitter pill to swallow. Very big. It wasn't until 2020 that they were tried together at the right dosages. I got very close in 2009. I was taking all four of the right drugs, but at the wrong dosages. Nortriptyline was too high and lamotrigine was too low. I followed some of my doctor's suggestions. He has been extremely open-minded all the way. But these drugs and the dosages I felt would work were cobbled together by me - not through theory, but through the results of past empirical experimentation. If you could allow yourself to be dumb for just a couple of minutes, identify all of the drugs that helped - even a little. Identify all of the drugs that made you moderately to severely worse. Take your list of good ones and evaluate which ones are compatible in combination, but are different enough to be complementary rather than synergistic.

This is not a recipe meant to cure everyone. It is not even a recipe that is necessary to cure anyone except for me. However, I think this approach might be overlooked sometimes when we get too caught up with trying to figure out the most complex object in the universe.

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

Re: 120mg of fluoxetine

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