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Re: Anyone ever augment a TCA with Zoloft or Remeron?

Posted by linkadge on December 26, 2018, at 13:00:59

In reply to Re: Anyone ever augment a TCA with Zoloft or Remeron?, posted by Schlepo on December 26, 2018, at 10:33:03

Hey,

Nortriptyline and/or desipramine seem to be the most talked about (and perhaps studied) TCAs for augmentation purposes. I think the rationale is that, they are primarily noradrenergic and so the mechanism would complement an SSRI.


I have heard more about nortriptyline with sertraline (for some reason). However, I'm not sure if it is more effective than other combinations. Nortriptyline tends to be better tollerated than say amitriptyline (less sedation and fewer anticholinergic side effects).

Linkadge



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