Posted by bleauberry on December 17, 2018, at 14:31:45
In reply to roboxetine and desipramine, posted by rjlockhart37 on December 14, 2018, at 16:23:21
I have taken both of these meds.
Desipramine feels like what you would expect from a TCA - dirty, antihistamine, with an adrenal kick that can make your heart skip or butterflies in your stomach. I could not tolerate it long enough, even on a low dose, to give it a good try. It was too stimulating physically, crazy in the brain, and just didn't feel right. But it did give me a hint that I needed to go that direction and away from the serotonin direction.
I later found much better results from Milnacipran, which is clean, with 2 parts NE to one part 5ht. Super low dose worked pretty good.
Reboxetine was a nightmare. It was deep dark dungeon-like depression within hours of taking the first dose. I think if someone wanted to purposely make someone else super depressed, give them a heavy NE drug like reboxetine. That said, I understand clinical studies looked good and some people do well with it. Looking at the fine details of those studies, I don't trust their conclusions.
If you are interested in the norepinephrine angle then I would consider these: Milnacipran (Savella), Nortriptyline, Adderall, Modafinal, Ritalin. My personal fav on that list is Ritalin by a long shot. It helps more people with more symptoms than any other drug a doctor writes prescriptions for.
poster:bleauberry
thread:1102429
URL: http://www.dr-bob.org/babble/20181024/msgs/1102477.html