Posted by Tomatheus on March 15, 2016, at 20:51:58
In reply to Re: Too much Serotonin? » linkadge, posted by J Kelly on March 15, 2016, at 20:03:45
> Is anyone familiar with a med that actually lowers serotonin?
Jade,
There's some reason to think that tianeptine, which is sold under the trade name of Stablon in some countries, might enhance the reuptake of serotonin instead of inhibiting it like many first-line antidepressants do. According to McEwen et al. (2010), tianeptine has been found to reduce the extracellular levels of serotonin in older rat studies, and the medication has also been found to reduce the number of serotonin transporter sites and the mRNA levels of these sites in the dorsal raphe nuclei of rat brains. However, more recent studies have shown that acute and long-term administration of tianeptine to conscious rats does not produce either a marked increase or a marked decrease in extracellular serotonin levels in corticolimbic brain structures (McEwen et al., 2010). The authors explained further: "From an electrophysiological point of view, sustained administration of tianeptine did not modify the spontaneous firing rate of serotonergic neurons in the dorsal raphe, nor did it modify the activity of postsynaptic 5-HT1A receptors nor the effectiveness of the terminal 5-HT autoreceptor antagonist in increasing the efficacy of the stimulation of the 5-HT pathway, despite prolonged treatment."
So, even though some earlier rat studies have suggested that tianeptine might act as a serotonin reuptake enhancer, more recent studies have called the initial findings into question. Tianeptine is also being discussed in another thread here on Psycho-Babble, which can be found here:
http://www.dr-bob.org/babble/20160306/msgs/1087150.html
Tomatheus
==
REFERENCE
McEwen, B.S., Chattarji, S., Diamond, D.M., Jay, T.M., Reagan, L.P., Svenningsson, P., et al. (2010). The neurobiological properties of tianeptine (Stablon): From monoamine hypothesis to glutamatergic modulation. Molecular Psychiatry, 15, 237-249. Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902200/
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poster:Tomatheus
thread:1087183
URL: http://www.dr-bob.org/babble/20160306/msgs/1087215.html