Posted by linkadge on March 11, 2016, at 21:24:49
In reply to Re: Trying methylfolate, posted by SLS on March 11, 2016, at 17:19:30
Hi SLS.
Methylation is a complicated process, of which I know little! Methyl donors such as folic acid, b12, b6, trimethylglycine, choline, can increase SAMe production which has effects on the three primary monoamines as well as membrane function. The antidepressant effect of folates could thus be related to improved SAMe synthesis. However, I remember reading that SAMe can really lead to profound increases in dopamine vs. other monoamines. This might wreak havoc on dopamine stabilization in bipolar.
I remember reading a study in which mice were fed high levels of several methyl donors at a time. They ended up developing 'schizophrenic like' symptoms, which could be reversed by HDAC inhibitors like valproate. SAMe is notorious for exacerbating mania in bipolar, possibly due to its strong dopaminergic effect.
One issue with deplin could be the dose. It may be possible to have a folate deficiency that is overwhelmed by 7.5-15mg of methylfolate. Lower doses could prove more effective.
The OTC supplement I purchased has only 1mg in it and I am only starting with a fraction of a capsule. I can definitely notice the effect.
Linakdge
poster:linkadge
thread:1087015
URL: http://www.dr-bob.org/babble/20160306/msgs/1087060.html