Re: low dose abilify as a add-on to move my butt » Noa

Posted by SLS on December 24, 2015, at 20:09:24

In reply to Re: low dose abilify as a add-on to move my butt » SLS, posted by Noa on December 24, 2015, at 12:14:37

Hi, Noa.
It's nice to see your name magically appear.
:-)
> So I finally got around to talking to the MD about adding Abilify. He agreed and said he would add it to my current cocktail rather than replacing the nefazodone.
>
> As for why I started on Nefazodone in the first place---I needed more AD effect but couldn't go higher on the Effexor dose (issues with memory, word retrieval, muscle spasm, sleep). I think it was the 5Ht2 antagonist action that was supposed to be key because I was having terrible restless legs at night (I also take Lorazepam for this).
>
> I just started the Abilify..only on 1 mg so far, with plan to go up to 2 mg. I started by taking it in the morning but found myself feeling drowsy (a little high even), so I switched to taking it at night, which the doctor had suggested. But last night I had restless legs for no other apparent reason (hadn't had caffeine, etc.) and I am wondering if I should go back to taking the Abilify in the day. But if it has 5 HT2 antagonist effects, it shouldn't be causing restless legs, should it?
5-HT2a antagonism by itself shouldn't cause or reverse RLS. It might be caused by dopamine D3 receptor blockade and some D2 blockade.
Abilify can cause RLS as a side effect. I am a bit surprised to learn this. Maybe it is a startup side effect. A lot of people experience akathisia-like symptoms during the first week or two of taking Abilify. It usually dissipates completely. Maybe the same is true of the side effect you are experiencing.
There is a new FDA-approved Abilify-like drug called Rexulti (brexpiprazole). It might have a reduced tendency to produce RLS, but I'm not sure. It blocks D2 more than D3 compared to Abilify, but retains the dopamine receptor partial agonist property. Apparently, Rexulti has some biological effects that are similar to those of antidepressants.
What are you taking right now?

- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.
- George Bernard Shaw

Thread

low dose abilify as a add-on to move my butt JohnLA 1/5/12
...
thanks scott JohnLA 1/8/12
thanks scott JohnLA 1/8/12
Re: thanks emme-V2 JohnLA 1/8/12
Re: thanks emme-V2 » JohnLA SLS 1/8/12
thank-you scott JohnLA 1/8/12
Re: thank-you scott » JohnLA SLS 1/8/12
Re: low dose abilify as a add-on to move my butt creepy 1/15/12
Re: low dose abilify as a add-on to move my butt Noa 7/29/15
Re: low dose abilify as a add-on to move my butt » Noa SLS 7/29/15
Re: low dose abilify as a add-on to move my butt » Noa phidippus 7/30/15
Re: low dose abilify as a add-on to move my butt » Noa SLS 7/30/15
Re: low dose abilify as a add-on to move my butt » SLS Noa 12/24/15
Re: low dose abilify as a add-on to move my butt » Noa SLS 12/24/15
Re: low dose abilify as a add-on to move my butt » SLS Noa 12/25/15
Re: low dose abilify as a add-on to move my butt » Noa SLS 12/25/15
Re: low dose abilify as a add-on to move my butt » SLS Noa 12/25/15
Re: low dose abilify as a add-on to move my butt » SLS Noa 12/25/15
low dose abilify as a add-on to move my butt -Oops » Noa SLS 12/25/15
Re: low dose abilify as a add-on to move my butt -Oops » SLS Noa 12/26/15
Re: low dose abilify as a add-on to move my butt -Oops Lamdage22 12/30/15
Re: low dose abilify as a add-on to move my butt -Oops SLS 12/30/15
Re: low dose abilify as a add-on to move my butt -Oops Lamdage22 12/30/15
Re: low dose abilify as a add-on to move my butt -Oops SLS 12/30/15
Re: low dose abilify as a add-on to move my butt -Oops » Lamdage22 Noa 12/30/15
Re: low dose abilify as a add-on to move my butt -Oops Lamdage22 1/12/16
...
Re: low dose abilify as a add-on to move my butt -Oops SLS 1/12/16

Post a new follow-up

Notify the administrators

Start a new thread

poster:SLS thread:1006480
URL: http://www.dr-bob.org/babble/20151119/msgs/1084947.html