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Re: Dysautonomia caused by Seroquel and other APs » linkadge

Posted by SLS on December 21, 2015, at 17:08:07

In reply to Re: Dysautonomia caused by Seroquel and other APs, posted by linkadge on December 21, 2015, at 11:11:41

> Seroquel (owing to NE reuptake inhibition, and alpha-2 antagonism) can mess with blood pressure and blood pressure regulation.

Yes. This is exactly why I asked the questions.

I would still like to know how dysautonomia was diagnosed. Certainly, mood disorders by themselves can affect autonomic function. However, dysautonomia proper is very unstable and can produce shifts in both directions. My guess is that depression shifts things in only one direction - a skewing toward increased sympathetic tone and reduced parasympathetic tone.

> I would come off of it, and try something like valproate. I have been on both lithium and valproate - which are both good for BP. Valproate is better for anxiety.

I found valproate to be a potent anti-manic, but it also worsened my depression to a moderate degree after a few weeks. Of course, other people might not experience this. At the time, anxiety was not a problem for me, so I can't comment on that. Perhaps Lyrica (pregabalin) would help. Actually, adding Lamictal to lithium might be an avenue to explore. Although not known as an anxiolytic, its antidepressant effects might reduce any anxiety that might be attendant to unrecognized residual depression.

How long do you think it would take valproate to exhibit anxiolytic effects?


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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