Posted by SLS on November 12, 2015, at 7:01:09
In reply to Re: My meds and p450 liver metabolism (SLS and others), posted by Lamdage22 on November 11, 2015, at 23:21:02
> It looks like its complicated with Cannabidiol!! Check "drug metabolism".
>
> http://www.medicinalgenomics.com/wp-content/uploads/2013/01/Bergamaschi_2011.pdfThere is a lot of stuff there.
Here is the summary offered by the article:
"In summary, the metabolism of drugs by cytochrome P450s 3A, 2C and 2B subfamilies can be affected when CBD in simultaneously administered. On the other hand, CBD extracts or Sativex do not seem to inhibit or induce hepatic CYP450, probably because the administration of CBD and THC is simultaneous, which avoids the pharmacokinetic interaction, in addition to the fact that the dose ratios are very low (=1) to induce pharmacokinetic blockade [118][119]."
Unfortunately, I can't find in the article the magnitude of P450 interactions described. Am I right in thinking that Seroquel might be a problem? I don't know.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1083961
URL: http://www.dr-bob.org/babble/20150929/msgs/1083969.html