Posted by SLS on September 28, 2015, at 7:23:12
In reply to Savella good for social anxiety study says:, posted by former poster on September 27, 2015, at 23:45:20
> Why don't Doctors prescribe Savella (Milnacipran) for social anxiety?
>
> "Conditioned fear stress (CFS)-induced freezing behavior has been proposed as an animal model of anxiety especially social anxiety. CFS-induced freezing is attenuated by the acute administration of milnacipran as well as the SSRIs, citalopram and fluvoxamine, whereas the selective NE reuptake inhibitor, maprotiline, was inactive (Hashimoto et al 1996). These results suggest an important role for the facilitation of 5-HT neurotransmission in the reduction of CFS-induced freezing behavior. A study in an analogous model in mice showed similar results with milnacipran and fluvoxamine inhibiting conditioned fear stress induced freezing behavior to a similar extent (Miyamoto et al 2004)."
>
> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654524/I don't mean to be trite, but mouse studies don't always generalize to humans. That's why clinical studies in humans and anecdotes reveal the true worth of a substance. Effexor has demonstrated efficacy in GAD and SAD in humans. If Effexor doesn't work and you are committed to trying Savella (milnacipran), you might want to take a look at Fetzima (levomilnacipran), a Savella isomer. I would go with Fetzima if you find evidence that it is better for depression. I couldn't find any studies offering direct comparisons. It is supposed to be more effective for depression according to some sources, though. I don't know if that can be generalized to SAD, but I think it's a good bet. If that doesn't work, there is always Nardil and Paxil.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1082969
URL: http://www.dr-bob.org/babble/20150901/msgs/1082974.html