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Re: does lamotrigine cancel out dexedrine? » phidippus

Posted by SLS on August 5, 2015, at 23:46:59

In reply to Re: does lamotrigine cancel out dexedrine? » SLS, posted by phidippus on August 5, 2015, at 15:34:24

How do you interpret the article you cited?

For me, lamotrigine exerts little or no antimanic effect. I don't think I am unique in this regard.

The article you cited provides no mention of the nucleus accumbens. I think you will find that glutamate antagonizes dopamine circuits there. The afferent glutamatergic neurons might be projections from the thalamus, but I'm not sure. I'm thinking that maybe an increase in DA activity via disinhibition increases appetitive and reward responses. I could be very wrong, but I have not yet come across an adequate explanation as to why lamotrigine produces improvements in depression.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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