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Re: bloodwork » Chris O

Posted by SLS on July 4, 2015, at 14:03:29

In reply to Re: bloodwork » b2chica, posted by Chris O on July 4, 2015, at 10:58:40

It was recommended to me that I take 50,000 IU a week of D3 for low levels that were determined by a simple blood test.

Some genetic tests can be ridiculously expensive. What is it that is to be tested? Sometimes, certain variants of liver enzymes (cytochrome P450) metabolize drugs at different rates. I'm wondering if this is an issue.

Testing for the promoter gene that codes for the serotonin transporter (site of action of SRIs) can influence what drugs are chosen to treat depression. This remains controversial, though. At the very least, it might indicate how early in treatment a response occurs.

For the responsivity to serotonin reuptake inhibitors, the possible transporter allele (gene variants) combinations (genotypes) look like this:

L = Long allele = Rapid activity
S = Short allele = Reduced activity

L+L = Rapid and robust response to SRIs
L+S = Intermediate responsivity to SRIs
S+S = Much reduced responsivity to SRIs

S+S is the least common genotype in the general population. For people who are TRD posting on Psycho-Babble, I wonder if S+S isn't more common. Perhaps the addition of a tricyclic like nortriptyline would be a better choice in these cases.

* I would really like to know what tests you are supposed to have.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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URL: http://www.dr-bob.org/babble/20150629/msgs/1080220.html