Re: Ketamine and ketamine-like drugs

Posted by SLS on April 3, 2015, at 20:22:37

In reply to Re: Ketamine and ketamine-like drugs » linkadge, posted by europerep on April 3, 2015, at 7:37:32

> > Not necessarily. Ketamine also increases serotonin.
>
> That would still leave open the question of the almost instantaneous onset of antidepressant effects of ketamine. So even if its mechanism of action is similar to that of SSRIs (which I doubt), it still does it much better.
>
> It would be interesting to see whether patients who respond to (or even remit on) SSRIs also respond to ketamine.
I think it has more to do with glutamate neurotransmission that does not rely upon NMDA receptors. This would leave AMPA or kainate receptors. It may be that any increase or decrease in other neurotransmitter systems are only secondary to an increase in glutamate activity.

- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.
- George Bernard Shaw

Thread

Ketamine and ketamine-like drugs FredPotter 4/2/15
Re: Ketamine and ketamine-like drugs linkadge 4/2/15
Re: Ketamine and ketamine-like drugs » linkadge europerep 4/3/15
Re: Ketamine and ketamine-like drugs ikasug 4/3/15
Re: Ketamine and ketamine-like drugs linkadge 4/3/15
Re: Ketamine and ketamine-like drugs linkadge 4/3/15
Re: Ketamine and ketamine-like drugs SLS 4/3/15
Re: Ketamine and ketamine-like drugs Bill82 4/3/15
Re: Ketamine and ketamine-like drugs cadett 4/3/15
treatment resistant psychosis do's and don'ts take Jeroen 4/4/15
Re: Ketamine and ketamine-like drugs linkadge 4/5/15
Re: Ketamine and ketamine-like drugs linkadge 4/5/15
ketamine-like drugs eg GLYX-13 FredPotter 4/5/15
Re: ketamine-like drugs eg GLYX-13 Lamdage22 4/6/15
Re: ketamine-like drugs eg GLYX-13 paulk 11/22/15
to paulk count me in Jeroen 11/22/15

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