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Re: Ketamine and ketamine-like drugs

Posted by SLS on April 3, 2015, at 20:22:37

In reply to Re: Ketamine and ketamine-like drugs » linkadge, posted by europerep on April 3, 2015, at 7:37:32

> > Not necessarily. Ketamine also increases serotonin.
>
> That would still leave open the question of the almost instantaneous onset of antidepressant effects of ketamine. So even if its mechanism of action is similar to that of SSRIs (which I doubt), it still does it much better.
>
> It would be interesting to see whether patients who respond to (or even remit on) SSRIs also respond to ketamine.

I think it has more to do with glutamate neurotransmission that does not rely upon NMDA receptors. This would leave AMPA or kainate receptors. It may be that any increase or decrease in other neurotransmitter systems are only secondary to an increase in glutamate activity.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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