Re: Low dose antipsychotics increase dopamine?

Posted by linkadge on March 28, 2015, at 16:23:30

In reply to Re: Low dose antipsychotics increase dopamine? » Chinaboy, posted by SLS on March 28, 2015, at 8:33:34

Hi Chinaboy:
This seems like a bit of an overkill prescription if you are not currently on these meds.
For instance, it would seem reasonable to start with Prozac OR Wellbutrin first and see what happens. I would not add the others unless needed.
The logic here might be that Prozac and wellbutrin would be too stimulating and thus the olanzapine could help offset this.
As mentioned by SLS, olanzapine can increase dopamine release to some extent through blockade of dopamine receptors. Additionally, olanzapine blocks serotonin and acetylcholine receptors which can inhibit dopamine release. Lower doses may preferentially block 5-ht2a / 5-ht2c receptors which can increase dopamine release in certain brain regions.
Linkadge

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Low dose antipsychotics increase dopamine? Chinaboy 3/27/15
Re: Low dose antipsychotics increase dopamine? Chinaboy 3/28/15
Re: Low dose antipsychotics increase dopamine? » Chinaboy SLS 3/28/15
Re: Low dose antipsychotics increase dopamine? linkadge 3/28/15
Re: Low dose antipsychotics increase dopamine? rjlockhart37 3/29/15
Re: Low dose antipsychotics increase dopamine? Christ_empowered 3/30/15

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