Posted by Robert_Burton_1621 on February 24, 2015, at 11:06:31
In reply to Re: Brain Signature for Melancholia Identified, posted by ed_uk2010 on February 23, 2015, at 13:48:14
> I think it's interesting. I'd like to see more studies looking at the relationship between specific neurological abnormalities and treatment response... rather the the usual symptoms and treatment response.
>Yes, that seems like the logical next step. At the moment, the research team is recruiting subjects in order to test whether the initial results are replicable, and to obtain a greater degree of statistical significance. The authors also noted that, owing to ethical considerations which militated against very ill melancholic subjects being taken off their medication for the duration of their participation in the study, it's not entirely clear whether medication may not have had some clinically relevant influence on the neuro-psychiatric dysfunction that was identified in the melancholic cohort.
Do you think this is possible and, if so, is it possible to minimise its potentially distorting effect through methods which don't involve withdrawal from medication?
poster:Robert_Burton_1621
thread:1076962
URL: http://www.dr-bob.org/babble/20150223/msgs/1077060.html