Posted by linkadge on February 16, 2015, at 16:50:25
In reply to Re: 5ht2c Agonists for BP Mania? (Lorcaserin), posted by ed_uk2010 on February 16, 2015, at 13:20:24
Stimulation of the 5-ht2c receptors can have the same effect as bright light, in altering sleep cycles. Thus, you could theoretically get insomnia.
5-ht2c stimulation might cause dysphoria (acutely) as these receptors supress the release of dopamine in rewards centers of the brain. But, there would likely be a rebound to this as the drug wears off.
5-ht2c agonists might also have anticonvulsant effects and antiagressive effects.
Most literature suggests that 5-ht2c antagonist are antidepressant. Therefore, it might be reasonable to suggest that 5-ht2c agonists might be depressant or at least anxiogenic. As mentioned, I think agonists might be acutely dysphoric / anxiogenic, with some rebound effect as the drug wears off.
Linkadge
poster:linkadge
thread:1076739
URL: http://www.dr-bob.org/babble/20150129/msgs/1076769.html