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Re: Effexor + Mirtazapine MORE effective than PARNATE! » linkadge

Posted by Robert_Burton_1621 on February 13, 2015, at 10:39:01

In reply to Re: Effexor + Mirtazapine MORE effective than PARNATE!, posted by linkadge on March 13, 2013, at 9:33:58

> From what I understand, californa rocket fuel just refers to effexor and remeron.
>
> Remeron has a noradrenergic releasing effect which could potentiate the NRI properties of effexor.
>
> Linkadge

Aren't the NRI properties of Effexor pretty weak, even at very high doses?

Desipramine 0.83 most potent
Amitriptyline 35
Fluoxetine 240
Venlafaxine 1060 weakest

See the table of data by PK Gillman relating to "dual action", at his psychotropical.com site:

http://www.psychotropical.com/index.php/anti-depressants/general-intro-4

And if Mirtazapine has no effect on the tyramine pressor response, which suggests a sub-optimal property of "releasing" (?) noradrenaline, how is it that two agents with seemingly weak noradrenergic potency would together optimise inhibition of its reuptake to a degree greater than, for instance, nortriptyline or amitriptyline?

I am a neophyte at al this (as is no doubt obvious!), though would like to learn more!


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poster:Robert_Burton_1621 thread:1040126
URL: http://www.dr-bob.org/babble/20150129/msgs/1076357.html