Posted by OneMind on January 31, 2015, at 17:19:18
In reply to Re: Experiencing Sedation with Parnate, posted by Charles Darwood on January 18, 2010, at 3:10:03
I also experience tremendous sedation on parnate (tranylcypromine), it eventually wears off a few hours after the dose, I'm just so surprised as it is widely reported that parnate is amphetamine-like and somewhat addictive. I also noticed that skipping a day makes the sedation the next day much worse.
Adding provigil helps somewhat, adding a stimulant helps tremendously (daytrana patch is nice choice), though I think this needs to be done with caution. I'm on parnate 30-40mg day.
As far as its efficacy in depression, WHAT A MIRACLE DRUG. Totally works for me, so grateful this drug exists. Blows SSRIs out of the water.
Another thing to consider, I know this has been discussed elsewhere. On the question if Parnate can cause a false positive on a urine drug screen for amphetamines, the answer is unequivocally YES. I don't know why. I'm not suggesting it is converted to amphetamine in the body. I'd suspect that the molecule is "similar enough" to bind to the antibodies used in standard screening tests. It probably varies from company to company, person to person and timing of dose in relation to the test.
Random piece of psychopharmacological advice: try N-acetylcysteine 1,000 twice daily. Lots of emerging evidence for this compound in a variety of psych disorders. I find its a really nice booster. Unfortunately, it will never get the full research attention it deserves as its over the counter and can't be patented by a drug company. Research suggests its operating on the NDMA/glutamate system, a neurotransmitter than thus far has eluded drug development in depression, with the recent exception of Ketamine.
poster:OneMind
thread:933452
URL: http://www.dr-bob.org/babble/20150129/msgs/1075826.html