Posted by linkadge on September 15, 2014, at 20:03:59
In reply to Re: TRK-b agonists for BDNF knockouts, posted by linkadge on September 15, 2014, at 19:57:40
BDFN is an interesting target. Enhancement of BDNF signalling interacts with P11 to enhance the surface expression of 5-ht1b receptors. It also can increase reward sensitivity via enhancing dopamine d3 expression. I think there is interaction too with gsk3. I think gsk3 inhibitors can enhance BDNF. I remember reading that ketamine's enhancement of BDNF was abolished if the effect of gsk3 was abolished.
I just have a surface knowledge though.
Linkadge
poster:linkadge
thread:1071129
URL: http://www.dr-bob.org/babble/20140914/msgs/1071189.html