Posted by Lamdage22 on August 30, 2014, at 8:43:37
In reply to Re: Is clozapine induced agranulocytosis reversible? » Lamdage22, posted by SLS on August 30, 2014, at 8:06:04
> > From what i have read and heard, Seroquel has the best side effect profile if you take away weight gain by using Metformin!
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> What about Saphris (asenapine)?Scott, weird, i asked for Saphris but it is only approved for bipolar mania where i am living! And i dont know the data on how frequently it causes motor side effects like and including tardive dyskinesia. Id only try it if it has the same low tardive dyskinesia incidence like Seroquel. And i would have to persuade a doctor to prescribe it(and pay it).
Do you have any data on Saphris's TD and motor side effect potential in relation to other atypicals?
I have seen it work to produce antipsychotic and antidepressant effects. It may be particularly well-suited to treat paranoia. You could add it to your ongoing Seroquel treatment, just in case it doesn't confer sufficient antipsychotic activity. If you feel good, then you can try discontinuing the Seroquel. I don't think Saphris causes as much weight gain as Seroquel. Seroquel does have the potential to produce diabetes, but probably not to the same degree as clozapine. Latuda (lurasidone) is an antipsychotic that is not supposed to cause weight gain. I am guessing that there would be a reduced risk of diabetes. Very few people have tried it yet, and I really don't know how effective it is as an antipsychotic. However, it does have antidepressant effects. It produces NE alpha-2 antagonism (similar to Remeron (mirtazapine)), as well as 5-HT7 antagonism (similar to Brintellix (vortioxetine)).
I tried Latuda (for like 1250 bucks a month.) Sedation and akathisia at once made me finish the experiment early! It was pretty unpleasurable.
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> - ScottIn what areas do you suspect Saphris to be superior over Seroquel? Weight gain is not an issue as i take Metformin. Diabetes however would be an issue. As would be tardive dyskinesia. Those are my biggest concerns. TD almost more so than diabetes, as it is incurable in nature and literally makes you look like a moron. I can imagine future better diabetes treatments than now. Not so for TD.
Regards. Julian
Schizophrenia and Depression
Seroquel 800mg
Zyprexa 5mg
Lithium orotate 480mg
Metformin 1500mg
Effexor 20mg
poster:Lamdage22
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