Posted by LouisianaSportsman on May 11, 2014, at 22:35:28
In reply to invega or risperdal?, posted by iowamoo on May 10, 2014, at 17:41:24
> Yes I'm back and still trying to rule out different medsosoooooo any opinion between these two please let me know and thanks so much for your patience!
From what I can remember when I was selecting AAPs (I have taken Abilify, and I now take Latuda), I'm not going to do any Googling for you, I know that's not the kind of answers you want anyway.
I would say that paliperidone would be the superior option only if it is not a financial burden.
Only in certain cases would Invega offer much of an advantage over Risperidone to warrant much of an extra cost.
The main advantage it offers is that it is the active metabolite of Risperdal and as such as there are no drug-drug interactions with paliperidone (low extent of enzymatic metabolism with already metabolized formulations); also,age does not factor in with the pharmokinetics of Invega if you're older I believe.
Remember that these two are not approved for the depressive phase of bipolar disorder and may very well INCREASE DEPRESSION, but may be effective for mania or treatment of bipolar disorder. There may be studies with Invega where the HAM-D (depression) score is higher at endpoint, but the mania score is lower; therefore, Invega is successful, but only technically so in my eyes. Watch out for an increase of depression with Invega or Risperdal; however, paliperidone is more likely to act as a mood stabilizer with properties similar to lithium via protein expression analysis. Regardless of this fact, I still had to rule it out for my bipolar depression, but I still think it has a merit for treating bipolar marked with particularly manic symptomology.
Invega is also lot of better in terms of glucose, cardiovascular health and metabolic side effects like hyperglycemia and lipid dysregulation than the majority of AAPs but remember your endocrine stuff is not good due to the prolactin increase and the extrapyramidal symptoms are no good but still beats Risperdal and a lot of AAPs-- but these are dose dependent as with all things are in the AAP world.
It's a great option if you're schizophrenic and I believe OROS sustained-release of it is quality (you will sh*t out and be able to see the shell of it!) (same thing in Concera, made by Alza Corporation).
If you need to things to be metabolized by your liver and you're prone to extrapyramidal side effects and need something with a better profile and have some extra money then strongly consider Invega. Don't expect it to do anything amazing for you off-label either.
Any other questions? Don't expect everything I said to be perfect because I didn't have time to research and look up things, sorry.
You'll most likely be better off with Risperdal since it will do everything you want cheaper.
poster:LouisianaSportsman
thread:1065457
URL: http://www.dr-bob.org/babble/20140419/msgs/1065508.html