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Re: Any new Anti-depressant is available?

Posted by Louisiana Sportsman on April 22, 2014, at 14:12:49

In reply to Any new Anti-depressant is available?, posted by HappyGirl on April 22, 2014, at 10:14:28

Zyprexa/Olanzapine 5 mg., Bupropion 150 mg. bid, Trazodon 100 mg. one for before bed. along with Lithium 300 mg. tid.
>
> Recently, however my mood-swing getting more often during the day, then I increased double-dosage to 10 mg.(2/5mg. per day) and my mood-swing getting better.
>
> 'morning sluggishness,' my depression is still there. I can not tolerate any of SSRIs.
> alleviate the depression side of my Bipolar II?
>

The olanzapine 10mg. is likely the main culprit here for the morning sluggishness.

There is an atypical antipsychotic approved for bipolar depression, that is fairy new, called Latuda (lurasidone [Sunovion]). I believe it superior to all APs.

Check out this study that compares Latuda to Zyprexa:

http://www.ds-pharma.com/ir/library/presentation/pdf/eir20110125_1.pdf

*insulin, glucose, lipid, and weight change are positive with Latuda and very negative with Zyprexa

Also, Latuda has:

*least QT interval prolongation, no warning about it required
*little weight gain, some studies showed weight loss compared to placebo
*less metabolic risk; better with cholesterol, hdl, ldl, triglycerides, prolactin and glucose, some studies showed loss in all categories compared to placebo
*little sedation, some studies showed less sedation

I'd consider switching your AP before adding in an anti-depressant, and I believe the best choice is Latuda. Talk to your doctor.


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poster:Louisiana Sportsman thread:1064656
URL: http://www.dr-bob.org/babble/20140419/msgs/1064673.html