Posted by tom2228 on March 18, 2014, at 21:29:46
In reply to Re: TCAs calming vs. sedating/ nortrip vs. Saphris SLS » tom2228, posted by phidippus on March 18, 2014, at 18:01:42
> > but the least anticholinergic among the TCAs?
>
> You're still going to get anticholergenic effects.
>
If you or anyone has taken Zyprexa, how does the anticholinergic effects of TCAs compare? Olanzapine is pretty potent at the mAChRs and H1. I'm not really anxious about the anticholinergic effects, more so the sedation.The sedation could be good though. I decided to take a Zyprexa 2.5mg tonight b/c I'm counting the days to the appointment on Monday.. it's just calming.. every time I take it it reminds me of how much better life can be without anxiety and maybe without all this dopamine I'm taking in with Marplan and Mirapex.
> > What would you recommend if she says no to the MAOI + TCA combo?
>
> If she says no, try a TCA alone. I would recommend Clomipramine-especially since you suffer from obsessive ruminations.
>
> >for nortrip the numbers are 16.5 for SERT and 1.65 for NET
>
> Keep in mind nortryptaline:
> - Boosts neurotransmitter norepinephrine/noradrenaline
> - Blocks norepinephrine reuptake pump (norepinephrine transporter), presumably increasing noradrenergic neurotransmission
> -Since dopamine is inactivated by norepinephrine reuptake in frontal cortex, which largely lacks dopamine transporters, nortriptyline can increase dopamine neurotransmission in this part of the brain
> -A more potent inhibitor of norepinephrine reuptake pump than serotonin reuptake pump (serotonin transporter)
> -At high doses may also boost neurotransmitter serotonin and presumably increase serotonergic neurotransmission
>
> > Was Invega at all calming for you? How about for agitation?
>
> Perfect for agitation and very calming.Great. I need that calm, which I realize after having taken the Zyprexa tonight. hopefully Invega and/ or nortrip can do that for me without massive sedation or massive weight gain.
Thinking of trying nortrip at this point with or without the Marplan. Despiramine seems to have comparatively smaller AD effects among TCAs from what I'm reading.. but these are just studies; the med with the smallest AD effects could wind up "curing" me just as the MAOIs may not be the best for me.
The Zyprexa is telling me as I type, "I can't wait til this gets sorted out, you stop thinking about these things so much, and just chill."
>
> Eric
poster:tom2228
thread:1062693
URL: http://www.dr-bob.org/babble/20140307/msgs/1062749.html