Posted by LouisianaSportsman on March 8, 2014, at 8:01:42
In reply to Re: Brintellix Trial 10mg. @Eric, Scott, Lamdage22, posted by LouisianaSportsman on March 3, 2014, at 20:04:51
> > My reaction to asenapine was very similar to lurasidone. I felt better for a few days, and then began to deteriorate. I felt worse on it than off it. I attribute this to NE alpha-2a receptor antagonism. Both drugs do this. So do mirtazapine and idazoxan. All four of these drugs exacerbate my depression. I can't help but to conclude that NE alpha-2a antagonism is to blame. In the cases of lurasidone and asenapine, I think the 5-HT7 receptor blockade produced the initial improvement, only to be opposed later by the emergence of sufficient NE alpha-2 blockade to disrupt my mood. I think it was a matter of time dependence rather than dosage dependence.
> >
> > I am very anxious to see how people do on Brintellix. Eric (Phiddipus) has chosen to describe his response to Brintellix using words that I like to hear.
> >
> >
> > - Scott
>
> So you're hoping that the 5-HT7 boost without the malicious NE alpha-2a antagonism will be so b*d*ss enough to be an alternative to Parnate? I guess so if aripiprazole has been the most effective for you so far. How well do you do on run-of-the-mill SSRIs? I'm curious if it'll have a reuptake inhibition effect similar to that of a Cymbalta (duloxetine) SNRI type or your traditional SSRI, Prozac (fluoxetine) type. How well do you do on -xetine's?
>
> If you do OK enough and the 5-HT7 antagonism is significant enough, it might overcome the activity of MAOI; thus it would be a wise switch.
>
> Yeah, obvious Eric's input was in my subconscious when I brought this up at the PDOC today. I also liked his input, I am hoping for a similar result!
>
>Today is now Day 6 of Brintellix therapy, and I must say that I think I like it quite well thus far. There is a poster that mentioned they felt anxiolytic results this early in medicating, I believe.
I feel that I may be experiencing an induced hypomanic response in other words, an antidepressant response for most persons. I cannot say if my swing to hypomania from my recent depressive episode is caused by vortioxetine. I am up early, and I actually want to do activities outside my window in the real world.
If you want to call this mania, thats fine. But, Id say my depression levels have been reduced with Brintellix.
I dont want to solely exist inside the phony, yet well-developed, inner reality in my head. I was discussing with my girlfriend whether or not she preferred the external world or the internal world inside her head (and the things associated with it). I told her that I would have to pick my internal world which comprises my dreamscape and creativity. She told me that this choice wasn't typical and that most people, especially those who are underprivileged, do not have the luxury to develop a luscious internal world because they have too many external obligations. This really made me realize that I should attempt to exteriorize myself more.
I do not have a divination that my mania will be bombastic. The feeling that I acquire from vortioxetine administration is subtle yet potent. I would describe my response compatibly to my initial response to the atypical antipsychotics Abilify (aripiprazole) and Latuda (lurasidone). I didnt experience any physical side effects from any of the pharmacons Im discoursing, but I did get agile mental effects in terms of altering the way I ruminate about life. You dream it, you live it.
Side effects, there are none to report. I cannot attribute any symptoms to vortioxetine.
Scott, I'm not sure if you really care about my input, but I would go for this if you're only getting 35% symptom relief with Parnate (I read that somewhere recently, might be a really old post of yours).
Sorry about the delay, there wasn't much interest.
poster:LouisianaSportsman
thread:1061746
URL: http://www.dr-bob.org/babble/20140307/msgs/1062044.html