Posted by David Hanifin on January 10, 2014, at 23:43:20
I suffer from anxiety with PTSD and depression. Since September 2013 I've been on parnate and reached a maximum dose of 60mg in december (after a slow upwards tiltration)where I stayed for 4 weeks. At 60mg I did feel clouded somewhat and had low energy from the medication. I'm now down to 40mg which strangely is somewhat more stimulating than the 60mg due to the 5ht receptor playing a bigger role at 60mg. Overall this antidepressant has been quite good and has made me somewhat more assertive however I don't think I have gotten near full remission of my symptoms and sometimes feel a little flat and the memory is somewhat affected. I've also had zero hypertensive episodes but the occasional orthostatic hypotension at 60mg.
After having been in this forum and hearing user reviews and reading psychiatry journals online I strongly feel that Nardil will easily give me more of a therapeutic response. Afterall it is labelled the 'anxiety gold standard'. The problem: Nardil causes weight gain 'significantly' in most people in the real world and in 'subjects' through studies. The reason I stopped Ssris in the first place was the Significant Weight gain (I'm already overweight) and to some degree the eventual numbness and apathy. In the past I have tried Reboxetine on its own and the weight loss and appetite control is nothing short of amazing over 'ANY agent I have ever tried. I have even combined a low dose Reboxetine with Zoloft and still had amazing results in the weight department but only partial remission of symptoms. I know it is 'likely' safe to combine a low dose Reboxetine (erdonax, prolift) (NRI) with Nardil and have read on forums that people taking this combination have limited side effects of weight gain, sexual dysfunction, hypotension, hypertension and low energy.
How do I convince my Australian psychiatrist to trial me on such a combination? Are there are 'any' studies or journals where this has been tried (he likes evidence)?
In the past I have tried moclobemide (RIMA) for about 3 weeks but I feel this isn't the ideal drug as one minute I'm depressed the next minute I'm happy and the next minute I'm disorientated. Also there isn't any evidence moclobemide works for anxiety and/or PTSD. Most people on forums for many years have also stated it wasn't an ideal drug for full remission even though side effects were somewhat limited.
Do you think my psychiatrist may bite the bullet and give me a shot at the Nardil + low dose Reboxetine combination? Any user reviews and/or case studies journals that people know about the combination would be GREATLY appreciated.
Thanks heaps Folks :)
David
poster:David Hanifin
thread:1058242
URL: http://www.dr-bob.org/babble/20140104/msgs/1058242.html