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Re: magic bullet found -) minocycline » Jeroen

Posted by SLS on January 4, 2014, at 4:57:21

In reply to magic bullet found -) minocycline, posted by Jeroen on January 3, 2014, at 23:27:19

> magic bullet found -> minocycline
>
> I THINK.... : D
>
> i should have kept taking it at lower dose, damn this forced psychiatry anxiety works on my nerves
>
> the startup side effects werent a laugh either still.... i feel much better (for how long it will last)

What were the startup side effects?

Please post at least twice a day. I would like to see you get more support during these first few weeks of taking minocycline. You might need the reassurance. You are not always a patient patient. :-) Neither am I, for that matter.

You might have to get up to 200 mg/day of minocyclne to get the most consistent benefit. I can't predict for you how quickly you will be able to get there. Maybe 100 mg/day will be enough, but I doubt you can maintain a therapeutic response at a dosage any lower than that. Meanwhile, you are doing the right thing for yourself - start low and go slow. I didn't begin taking 200 mg/day until week 3. I could probably have gotten there in a week, but why take the chance of becoming prematurely discouraged by a startup side effect? You might quit for the wrong reasons. Go slow.

DO NOT GIVE UP ON THIS DRUG!


- Scott


--------------------------------------------

http://clinicaltrials.gov/show/NCT01809158

1. An open label study of 22 patients with treatment-resistant schizophrenia, using minocycline 150 mg/d for four weeks, reported an improvement in both positive and negative symptoms.

2. Two double blind trials have been carried out. In one study, 73 patients with schizophrenia of less than five years' duration were randomized to minocycline 200 mg or placebo for 12 months: "all symptom measures improved significantly" especially in the negative symptoms. In the other study, 54 "early phase" (symptoms of less than five years) patients were randomized to minocycline 200 mg/d or placebo for six months; the authors reported a significant improvement in negative symptoms measured using Scale for the Assessment of Negative Symptoms (SANS) and Clinical Global Impressions scale (CGI) and a significant improvement in some test of executive function.

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http://clinicaltrials.gov/show/NCT01433055

Minocycline Dosing:

Minocycline (Dynacin® or generic) will be available in 50, 75 and 100 mg capsules. There will be matched placebo-minocycline capsules for each minocycline capsule strength. During the first week subjects will receive one 50 mg capsule twice per day (minocycline 100 mg total or matching placebo) and during weeks 2-10 subjects will receive 2- 50 mg capsules twice per day If a subject should complain of any side effect, then the blind psychiatrist will be allowed to omit the next dose of study medication and then continue the subject on the optimal treatment dose. If, despite this intervention, the subject is still unable to tolerate the 200 mg/day dose, then the dose may be lowered to 150 mg to alleviate side effects and minimize attrition.

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Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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