Posted by ed_uk2010 on December 13, 2013, at 14:54:36
In reply to Parnate help: drug interaction, posted by kirbyw on December 12, 2013, at 20:04:39
Hi Rick.
>I have been having attacks of shortness of breath, but my cardiac exams are ok.
What is the cause of these attacks? Do you think they are anxiety related? Do you feel a sense of panic? Also, have you ever suffered from asthma? Please can you list your medical problems/history and any other medication you take apart from Parnate. It may be appropriate to see a lung specialist. Does your chest feel tight when you have these attacks? What does it feel like?
>And both medicines suggested by my cardiologist (here in Costa Rica) are contraindicated with MAOs. (Salbutamol and trimetazidine) So does anyone know of anything that can help attacks of shortness of breath that are MAO compatible?
Trimetazidine is normally used to prevent angina. Do you suffer from chest pains? Why are you seeing a cardiologist specifically?
Salbutamol is a bronchodilator which relieves asthma attacks and COPD. There is very little evidence or logic behind the idea that standard doses of salbutamol are unsafe for patients on MAOIs. There appears to be a single case report of a man on an MAOI who felt rather anxious and suffered increased heart rate after using a salbutamol inhaler, but these are common side effects of salbutamol anyway. Salbutamol is a short-acting drug, so the effects will wear off fairly quickly if it doesn't suit you. It does tend to increase heart rate and cause a fine tremor of the hands. On the other hand, it can certainly relieve breathlessness caused by bronchospasm. It should be used with caution if you have coronary heart disease.
Salbutamol does not cause hypertension when combined with MAOIs. It should not be confused with related drug which do eg. ephedrine, pseudoephedrine. These drugs have a different mechanism of action to salbutamol.
Salbutamol by mouth causes far more side effects. Only the inhaler is recommended for asthma.
Take care.
poster:ed_uk2010
thread:1056037
URL: http://www.dr-bob.org/babble/20131209/msgs/1056068.html