Posted by ed_uk2010 on November 13, 2013, at 14:45:54
In reply to remeron sleep, posted by marcus1968 on November 12, 2013, at 22:08:26
>How can this tiny speck be so potent?
Mirtazapine has extremely high affinity for histamine H1 receptors. Its sedative antihistamine effect therefore occurs even at very low doses and does not increase when the dose is increased beyond a certain point because the H1 receptors in the brain are already saturated. Much higher doses are needed for depression as opposed to sleep because blocking H1 receptors does not exert an antidepressant effect... and mirtazapine's action on other receptors only occurs at higher doses.
Unfortunately, because mirtazapine is relatively long-acting, it does tend to cause a 'hangover' effect. Antihistamines with a shorter duration of action such as diphenhydramine (original Benadryl) may cause less hangover, but may not be as potent at inducing sleep as mirtazapine.
poster:ed_uk2010
thread:1054219
URL: http://www.dr-bob.org/babble/20131025/msgs/1054272.html