Posted by linkadge on November 9, 2013, at 19:34:00
In reply to Re: trimipramine vs remeron » linkadge, posted by Legm82 on November 8, 2013, at 19:47:29
I think some degree of tolerance can develop to any medication. I don't think it is bound to happen in all cases.
I think the 5-ht2a antagonist medications are more 'disease modifying' for insomnia. 5-ht2a receptors interact with melatonin and gsk-3b which might regulate the circadian rhythm in a more sustainable way. Drugs like mirtazapine, trazodone, seroquel, doxapin etc. can be used effectively for insomnia for years, perhaps indefinitely.
This doesn't mean that one will sleep every single night, but that they can normalize certain cases of chronic insomnia
poster:linkadge
thread:1053603
URL: http://www.dr-bob.org/babble/20131025/msgs/1054084.html