Posted by tensor on October 18, 2013, at 16:08:02
In reply to Re: Parnate - raise or augment?, posted by LouisianaSportsman on October 18, 2013, at 13:43:52
> I'd love to analyze this for you. I spend a lot of time doing this kind of thing, but I need to know what you're currently taking and what medications were not efficacious for you in the past.
>
> I'd suggest, based on my limited understanding, that augmenting with Lamictal would be a good idea. At 50mg. of Parnate, you're more likely to develop more side effects than therapeutic benefits. Lamotrigine is a great medicine to augment with tranylcypromine. Still, I'd try 60mg. of the tranylcypromine and begin a slow titration with lamotrigine.
>
> What condition are you trying to treat? This would help us betting pinpoint augmentation agents.
>
> Thanks!Hi!
I'm trying to treat recurring unipolar depression without melancholia and also anxiety. Tranylcypromine seems to work pretty well for anxiety although it's not 100% effective, I guess it has todo with my unresolved depression. I currently take 40mg of tranylcypromine and 2mg of clonazepam.
I have tried 30+ medications and many combinations, as a matter of fact always at least two medications except when I started medicating many years ago. It's easier to list some of the combinations that have worked as I can't remember them all. Nearly all of them have been in combinations with Remeron and clonazepam.
The following have worked with Remeron and clonazepam in the past (up to a year):
fluoxetine (for anxiety only)
clomipramine
sertraline
sertraline + bupropion (only 7 weeks)
nortriptyline
escitalopram + modafinil
Other combinations:
Seroquel + Lamictal + clonazepam
Seroquel + Lamictal + clonazepam + modafinilI'm fairly certain Seroquel messes with my cholesterol as it's normal now after I quit it. So I'm not so keen about restarting it. One thing though, Week 2 on tranylcypromine I was still on Seroquel and that week I felt much better, had a lot of energy several hours everyday. This may have been an initial transient response to tranyl or it was this combination with Seroquel. The thing is I decided to stop Seroquel because it caused a massive drop in blood pressure each time I took it that lasted a few hours, which in turn raised my pulse to 120, making it impossible to sleep.
I have had some hives (or whatever it is) from tranyl, in the beginning I could have three or four at the same time, although I get one now and then sporadically, they seem to appear less frequently. They are easily treated with some eczema cream and disappear after an hour or so, but it raises some concerns about starting Lamictal. I'm not sure how this affects the risk of getting the rash and I have started Lamictal twice before without a problem.Thanks,
tensor
poster:tensor
thread:1052459
URL: http://www.dr-bob.org/babble/20130930/msgs/1052500.html