Posted by psychobot5000 on October 11, 2013, at 22:10:55
In reply to Re: Antibiotic (doxycycline) treatment for depression, posted by hadmattress on October 11, 2013, at 20:13:09
My curiousity is certainly piqued. Re: presence of iron in certain brain regions, must note that correlation is not causation. Still. Anyone with relevant nutritive/pharmaceutical expertise able to comment?
>
> I have a theory as to the etiology of some mental illness and why the tetracycline antibiotics are effective. Hear me out.
>
> I'm a 27 year-old woman who has been researching and self-treating mental illness (formerly Bipolar II) for about four years. I have to tell you an anecdote in order for you to understand my theory.
>
> Several months ago I began having a severe exacerbation of OCD, depression, tics, ADHD, compromised fluency of speech, acne, body dysmorphia (feeling like I didn't want to be in my own skin), dizziness, ataxia, psychosis and forgetfulness only to discover that the man I had been living with was a clinical psychopath and had been using the neurobehavioral toxicology research I imparted to him against me by putting large doses of iron supplements in the food he cooked me. I got out of that situation immediately, but not without having suffered a pretty big hit to my mental and physical health.
>
> I put myself to work figuring out how to eliminate the iron. Now, you should know that I have been using the Andy Cutler protocol to chelate mercury after removing my mercury dental amalgams. His protocol helped me recover drastically (that's how I managed to turn my suicidal Bipolar II into unipolar anhedonia/dysthymia), but I hit a plateau. "Maybe a lot of the symptoms I have experienced are related to iron toxicity, considering the fortification of food using non-bioavailable iron (beginning most substantially in the 1940s)." I researched, and sure enough, iron deposition in the basal ganglia is found in a lot of these disorders, including depression, Tourette's and OCD.
>
> I started researching iron chelators and learned that tetracycline antibiotics form insoluble complexes with iron, hence why you are told to take iron separately from them. Minocycline can be used after a stroke to chelate iron, which protects the brain from neuronal death from oxidative damage, inflammation.
>
> http://www.ncbi.nlm.nih.gov/pubmed/21998050
>
> So, I purchased minocycline in order to "clean up" my brain. Of course, iron feeds pathogens, which is how iron chelating antibiotics work-- they starve them out by sequestering the iron. Ferritin is not a good indicator of iron storage considering the body quarantines iron in the organs to protect itself during chronic illness and infection, so you can even appear to be anemic with iron overload (also copper deficiency which is sometimes (paradoxically) paired with copper toxicity due to biounavailable copper can cause iron overload). The body is refusing to give the iron to feed the pathogens, or cause further inflammation by releasing it into the bloodstream, but all this iron build-up in the organs is toxic.
>
> Here is the problem, Andy Cutler PhD says that you MUST take any chelator at a very low dose on the half-life. Taking it at a low dose allows the body to eliminate the heavy metals in a way that doesn't overload your bloodstream with toxins, causing all sorts of unwanted side effects. Your body's detoxification system simply cannot keep up with a large amount of toxic metals circulating for a few hours. Taking the chelator on the half-life prevents the metals from redistributing. Think of a chelator as little hands that pick up toxins: if there aren't a constant stream of hands to hold onto the toxins, the toxins get dropped causing more damage to tissues. The more hands (i.e. chelator), the more toxins are mobilized from tissues and thus a greater toxic burden when the drug is eliminated.
>
> When I received my minocycline, I started taking very small doses (10mg every 8 hours approximately). Most of my symptoms were significantly lessened, but I ended up having a hypersensitivity reaction after a couple weeks, which is (I'm sure you know) not uncommon with minocycline, and so I had to stop taking it. I am going to order doxycycline and try again with that. At the moment I'm taking deferasirox, another iron chelator, which is working well (as evidenced by the fact that I'm writing this to begin with).
>
> Anyway, just my two cents.
>
poster:psychobot5000
thread:872561
URL: http://www.dr-bob.org/babble/20130930/msgs/1052026.html