Posted by SLS on July 22, 2013, at 17:13:30
In reply to Re: Ketamine...whoa!, posted by chumbawumba on July 22, 2013, at 14:24:34
Ketamine must be delivered in a way that produces a steady blood concentration that remains within a narrow window for some minimum amount of time. If you go even a little too high in dosage, you forfeit the antidepressant response. In addition, the consequence of the short half-life of ketamine is a very short window of time within which the blood concentration would be therapeutic if the drug were delivered via IM injection, intranasally, or orally.
The values currently being worked with are: ketamine IV = 0.5 mg/kg body weight x 40 minutes.
Dose-response:
- Low dose = glutamate release decrease
- Intermediate dose (therapeutic) = glutamate release increase
- High dose = glutamate release decreaseIntravenous administration has been the most successful method to administrate ketamine for treating depression because it can reliably deliver the right amount of drug.
I wonder if ketamine could be delivered transdermally or orally using a controlled-release. I guess it depends upon how narrow the therapeutic window is.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1047574
URL: http://www.dr-bob.org/babble/20130706/msgs/1047634.html