Posted by SLS on May 15, 2013, at 6:35:50
In reply to Minocycline- could anyone come off their Antipsy.?, posted by Lamdage22 on May 15, 2013, at 3:41:07
> ?
For now, I would say no. Current investigations are studying the use of minocycline as an adjunct to APs. Minocycline seems to help more with negative symptoms than positive symptoms. However, there really isn't any definitive work to demonstrate this difference.
http://www.scirp.org/journal/PaperDownload.aspx?paperID=25108
Are you still experiencing EPS (akathisia) with your AP?
If you are considering taking minocyline, and are NOT experiencing EPS, I would suggest not making any other changes in your treatment until you have responded fully to minocyline for an extended period of time - maybe 6 months. I would then use a gradual taper of the AP. If you ARE experiencing EPS, perhaps it makes sense to attempt discontinuing the AP after only a few weeks. If you relapse, I would think restarting the AP would be indicated while continuing with the minocyclne.
I think you should first continue your trial of Geodon so that you might be able to discontinue Abilify. It is the Abilify that is most likely to produce akathisia. When first starting Geodon, one can experience anxiety, agitation, or insomnia. It might even appear to make akathisia worse without actually doing so. I kind of like Saphris, though.
The most studied dosage of minocyline when treating bipolar disorder is 200 mg/day. I am not certain about schizoid disorders, but without additional information, I would go at least that high. There are a few instances where 450 mg/day was used.
I hope you achieve full remission.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1043680
URL: http://www.dr-bob.org/babble/20130501/msgs/1043682.html