Posted by Englishman006! on May 12, 2013, at 1:34:07
In reply to Re: nardil tolerance and ensuing cognitive problems, posted by rose45 on April 25, 2013, at 7:22:52
> Have just read that if you are bipolar (which my psychiatrist thinks I am) then trazodone will not work for you. Any thoughts on this from anyone?
Hi Rose, I don't for a minute believe you have manic depression or bipolar as its now referred to. I'm surprised that dr's still diagnose people as bipolar, after a 'medication induced' hypomanic episode. My theory is that when you get depressed on an ongoing basis the receptors in the brain are starved of dopamine. In an effort to compensate (and this is purely my belief) the receptors become super sensitive allowing them to mop up any dopamine that is available. Then Nardil is introduced and for the first time in a long time dopamine becomes abundant. But the receptors super sensitive response results in mania. In effect too much dopamine transmission is now at work, until they desensitise gradually (adapt to the drug).
Unless you have experienced mania which was not drug induced, my guess is they have mis-diagnosed you. I would try stabilising the dose of parnate at it's minimal effective dose and VERY SLOWLY introduce Lamotrigine beginning at 25mg (any sign of rash discontinue immediately) for first week or so then slowly taper up over six weeks - under medical guidance, to 200mg. Provided lamotrigine doesn't interact with maois this should provide an antidepressant effect, it even acts as a mood stabiliser for resistant bipolar. The side effects are pretty benign. If all goes well perhaps you could reduce or wean off the the other meds..?
poster:Englishman006!
thread:1042294
URL: http://www.dr-bob.org/babble/20130501/msgs/1043537.html