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Re: Can antipsychotics+ antidepressants work together? » PrettyLady

Posted by tensor on March 3, 2013, at 0:24:00

In reply to Re: Can antipsychotics+ antidepressants work together? » phidippus, posted by PrettyLady on March 2, 2013, at 16:22:37

> So, if the antipsychotic blocks, and the antidepressant supports, isn't that two opposite things going on there?

Atypical antipsychotics are used in depression with lower doses because they behave differently than at higher doses. At lower doses the blockage of 5HT2A is stronger than that of D2, which gives a higher dopamine output. At higher doses, the D2 blockage becomes dominant and dopamine is suppressed, giving an antipsychotic effect.

/tensor


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