Hi BB.
> I think they do, but rarely. The only two likely to have any shot at that at all, in my opinion, are prozac and zoloft. More than likely though, numbness is usually the outcome. That's because there isn't a counter-balance for norepinephrine. That's why I like Savella so much. It does everything ssri's do and then a lot more. I've been on it two months now and have zero numbness, feeling significantly improved. Seemed worthless for 8 weeks and then kicked in nice in week 9. Straight up ssris? I think that's a bad idea. Two things will avoid the numbness. First, the dose has to be low enough, which means it will take longer to kick in. Second, there has to be a NE and/or DA component. Serotonin alone will not do the job and can actually make things worse.
I still contend that Effexor is more effective than Savella when treating depression and anxiety disorders. At therapeutic dosages, Effexor is a balanced reuptake inhibitor of both SERT and NET. In vitro work with synaptosomes does not tell the whole story of the pharmacodynamics in vivo.
http://www.ncbi.nlm.nih.gov/pubmed/23090625
- Scott
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