Posted by SLS on December 20, 2012, at 18:42:11
In reply to Re: NSAIDs and Antidepressants, posted by Trotter on December 20, 2012, at 18:16:04
> > > > Yet it is thought that reducing systemic inflammation is a path in treating depression! I'm not disputing that NSAIDs can interfere with antidepressants, I just don't understand the apparent contradiction. I'm sure there is a reason. Perhaps someone smarter than me can explain it.
> > >
> > > I've had a bit of a think about an explanation to this conundrum. I think I have come up with a plausible explanation.
> > >
> > > If one believes the hypothesis that depression is caused by systemic inflammation, as I do, then it stands to reason that the worse the inflammation then the worse the depression. Now the worse systemic inflammation the more likely it is that people will suffer from other diseases linked to inflammation, such as arthritis. What do people with arthritis and other chronic pain diseases take? Often it's NSAIDs. So it is entirely possible the corelation between NSAIDs and worse depression is due to the common underlying cause of increased systemic inflammation.
> >
> > Plausible.
> >
> > Along another line of evidence, one of the most common side effects of the pro-inflammatory drug, interferon, is depression.
> >
> >
> > - Scott
> >
>
> Isn't this the sort of cause and effect evidence that inflammation causes depression?
Yes. It is a pretty compelling observation.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1033368
URL: http://www.dr-bob.org/babble/20121217/msgs/1033411.html