Posted by gilmourr on October 12, 2012, at 15:41:00
In reply to Re: Nardil Anxiety/Hyperrflexia..SLS? » gilmourr, posted by SLS on October 12, 2012, at 9:02:37
> Hi.
>
> I'm sorry that I never got around to commenting on your situation. I don't know what it is that occurs with you at a dosage of 60 mg/day of Nardil that you feel is counterproductive. It is unusual. However, it is not unusual for it to take several days for MAO inhibition to recover after a reduction in dosage if Nardil. This is less of a problem with Parnate.
>
> What exactly happens at 60 mg/day?
>
> Why do you feel the need to add another drug to Nardil?
>
> I know you have answered these questions before, but I am still unclear on them.
>
> Adding nortriptyline has really helped me in the past. I would just add it gradually so as not to trigger a worsening of hypotension and urinary retention.
>
> It is great that you remain responsive to Nardil. It is a good sign. Be patient. You will definitely be able to tweak your treatment and find an optimal regime.
>
>
> - Scott
That's fine, I don't mind restating it.What happens at 60 mg is that my anxiety starts to incrementally come back (mildly) but I start having SEVERE depressive mood swings. Every 2-3 days for 4-6 hours I would become severely depressed. I knew it was bad when one night it hit me at 12 AM and I had to wander the streets till morning because I felt so bad and had to do anything.
When I came off the 60 back to the 45 mg the mood swings went away. But this time, coming back to the 45 mg I had massive cold intolerance, my anxiety wasn't helped as much and I had hyperreflexes to noises.
I think yesterday I figured out that the cold intolerance is due to a B12/B6 deficiency, because I took a lot 48 hours ago and I'm much more regular in respect to body heat. I'm sure the hyperreflexes might take some time. I also am starting to feel more sleepy/relaxed taking the B6/B12.
Apparently B6 is a MUST for GABA-T to be metabolized which is the enzyme that metabolizes GABA. So with B6 supplemented, GABA-T might be inhibited more, thus more GABA.
I wanted to add the Nortryptiline because even when I was at 45 mg with NO side effects, it helped my depression remit by 60% tops, and the anxiety was like 70%. I figured I can get higher, thus, lets augment it. Right?
Hopefully the B6/B12 brings my 45 mg back to what it felt like before.
poster:gilmourr
thread:1027396
URL: http://www.dr-bob.org/babble/20121009/msgs/1028444.html