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Re: Two questions about Serotonin syndrome.

Posted by phidippus on September 22, 2012, at 1:57:37

In reply to Two questions about Serotonin syndrome., posted by schleprock on September 19, 2012, at 21:44:22

>Has anyone here actually had it

Yes, I have.

>What are the most common symptoms that one can know are unmistakebly SS related?

Mild symptoms may only consist of increased heart rate, shivering, sweating, dilated pupils, myoclonus (intermittent tremor or twitching), as well as overresponsive reflexes

Moderate intoxication includes additional abnormalities such as hyperactive bowel sounds, high blood pressure and hyperthermia; a temperature as high as 40 °C (104 °F) is common

Severe symptoms include severe increases in heart rate and blood pressure that may lead to shock. Temperature may rise to above 41.1 °C (106.0 °F) in life-threatening cases. Other abnormalities include metabolic acidosis, rhabdomyolysis, seizures, renal failure, and disseminated intravascular coagulation; these effects usually arise as a consequence of hyperthermia.

The symptoms are often described as a clinical triad of abnormalities:

Cognitive effects: headache, agitation,hypomania, mental confusion, hallucinations, coma
Autonomic effects: shivering, sweating, hyperthermia, hypertension, tachycardia, nausea, diarrhea.
Somatic effects: myoclonus (muscle twitching), hyperreflexia (manifested by clonus), tremor.

>what do you do when you know you have it?

Stop any serotogenic medications. If you start to get a fever, go to the ER.

>is it possible to experience it from a particular dose (or overdose) of a single drug?

Yes.

>is it possible that the combination of two drugs that have a weak effect on serotonin could result in SS?

It is unlikely.

Eric


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