Posted by Exister on September 8, 2012, at 10:12:47
In reply to Nardil 45 mg to 60 mg (worse?) theory. PST PLZ, posted by gilmourr on September 8, 2012, at 2:22:27
> I was on 45 mg. My mood was pretty damn good. Like a 5/10 for depression from a 10/10 (SEVERELY BAD). My anxiety was reduced as well greatly.
> - was on 45 mg for 6 weeks.
>
>
> Now at 60 mg, my depression feels like a 7/10 (feelings of crying randomly start for hours). My anxiety is about the same.
> - on 60 mg for 3 weeks.
>
> I know that norepinephrine is a big deal for my depression, is it possible that because I'm going HIGHER that NE is going lower and I'm feeling worse? Everything else should be going up, SERT, Dop, melatonin, GABA. NE going down is the only answer for this.
>
> I think I need that stimulant. Or nortryptiline or ANYTHING WITH NE. I HATE DEPRESSION.Hi. Strange how you think NE is going down. What makes you believe this? I assume MAO inhibition of all mono-amines stays at the same ratio throughout treatment, esp in the early days of Nardil. What I do know is that side effects seem to re-appear with each dose increase of Nardil. They again settle given time.
Saying that, I also use MAOIs and have allways needed a tweak from an NRI of some sort. Currently Wellbutrin SR 300mg is working ok with my Marplan 90mg. I also taking amitriptyline which is 50% NRI. The combined effect seems pretty activating.
ExIlls: Social Phobia, Major Depression, OCD
Daily Meds: Isocarboxazid 90mg, Clonazepam 4mg, Bupropion SR 300mg, Quetiepine 50mg, Amitriptyline >100mg
poster:Exister
thread:1025112
URL: http://www.dr-bob.org/babble/20120830/msgs/1025126.html