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Re: Nuvigil / Provigil Effects » SLS

Posted by phidippus on September 3, 2012, at 23:50:45

In reply to Re: Nuvigil / Provigil Effects » phidippus, posted by SLS on September 3, 2012, at 23:05:23

I have no idea how it differs from Provivgil-I haven't looked into it.

This is pretty typical about what I find on Nuvigil:

"Mechanism of Action and Pharmacology

The precise mechanism(s) through which armodafinil (R-enantiomer) or modafinil (mixture of R- and S-enantiomers) promote wakefulness is unknown. Both armodafinil and modafinil have shown similar pharmacological properties in nonclinical animal and in vitro studies, to the extent tested.

At pharmacologically relevant concentrations, armodafinil does not bind to or inhibit several receptors and enzymes potentially relevant for sleep/wake regulation, including those for serotonin, dopamine, adenosine, galanin, melatonin, melanocortin, orexin-1, orphanin, PACAP or benzodiazepines, or transporters for GABA, serotonin, norepinephrine, and choline or phosphodiesterase VI, COMT, GABA transaminase, and tyrosine hydroxylase. Modafinil does not inhibit the activity of MAO-B or phosphodiesterases II-IV."

A long list of what it doesn't do.

HOWEVER, plenty of literature points to it effecting dopamine somehow.

Eric


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URL: http://www.dr-bob.org/babble/20120830/msgs/1024827.html