Posted by g_g_g_unit on March 26, 2012, at 20:46:07
I've read that Clonidine is a selective alpha-2 agonist that's capable of both suppressing and stimulating noradrenaline release at different doses. I'm also aware that it has an extremely long half-life (Wikipedia says 12-33 hours?).
I really can't tell what effects I can attribute to it. It helps with sleep onset (0.2-0.3mg), but I don't sleep particularly well. I also find that the next day, I feel a little blunted in certain respects - I'm less irritable and also feel less physically anxious but at the same time kind of 'dead'. Is it usual to expect some carryover effect into the next day?
As for its interactions with Parnate, it's hard to say. As I've mentioned, there's a blunting of physical stimulation, but I can't really tell what effect it's having on the mental stimulation-side of things. I feel kind of blank and overstimulated at times, which I tend to associate with too much noradrenaline, so either the Clonidine's not helping or potentiating that side of things?
poster:g_g_g_unit
thread:1014119
URL: http://www.dr-bob.org/babble/20120316/msgs/1014119.html