Posted by SLS on March 21, 2012, at 13:52:17
In reply to Re: Doxepin » Beckett, posted by tensor on March 21, 2012, at 13:17:07
> It makes me wonder though.. take venlafaxine for example which is supposed to be a clean TCA,
Venlafaxine does not block serotonin 5-HT2a receptors the way nortriptyline does.
Since trimipramine is a TCA stripped of reuptake inhibition, this is a clue that TCA might exert some of their therapeutic effects through other mechanisms.
I try not to be "too smart" when making treatment decisions. It is not so important what I know as what I don't know. Different is different. Why someone responds to Paxil and not to Zoloft is not well understood. Are they exactly the same drug with exactly the same pharmacology? Obviously not, even if the differences between the actions of these drugs are not yet understood.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1013487
URL: http://www.dr-bob.org/babble/20120316/msgs/1013558.html