Posted by linkadge on March 12, 2012, at 16:43:42
In reply to Why does lower dose of Remeron cause more sedation, posted by mogger on March 12, 2012, at 13:16:53
One theory is that there are two competing actions with remeron, the antihistamine and the alpha-2 adrenergic antagonist (which increases NE release).
Remeron is a stronger antihistamine, so it probably saturates the h1 receptors at lower doses. As the dose increases, the alpha-2 antagonist effect becomes more pronounced. Or so the theory goes.
Linkadge
poster:linkadge
thread:1012891
URL: http://www.dr-bob.org/babble/20120302/msgs/1012898.html