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Re: Do these symptoms/reactions sound familiar? » g_g_g_unit

Posted by SLS on January 27, 2012, at 6:27:50

In reply to Re: Do these symptoms/reactions sound familiar? » SLS, posted by g_g_g_unit on January 26, 2012, at 21:47:34

> > What about using guanfacine for ADD and as an anti-noradrenalin drug - NE alpha-2 agonist?
> >
> >
> > - Scott
>
> Unfortunately, guanfacine isn't available in Austraia .. only clonidine.


Well, you certainly know your stuff. I'll be very interested to know what you come up with.

Check out prazosin as an anti-noradrenergic. It was developed as an antihypertensive that has shown efficacy in PTSD and may also exert therapeutic effects for ADHD as monotherapy. Adding a stimulant to prazosin actually reduces its efficacy.

I am currently experiencing an improvement in bipolar depression by adding prazosin to my treatment regime.


- Scott


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http://www.medscape.org/viewarticle/457175

* [There is a typographical error: Prazosin is a alpha-1 antagonist, not a alpha-1 agonist].

Prazosin

Taylor Fletcher, MD[3] conducted a clinical trial of prazosin in order to explore the role of norepinephrine in the pathophysiology of ADHD and the potential mechanism of action of dextroamphetamine. Prazosin is an alpha-1 agonist. Stimulant medications operate through feedback loops that have secondary effects on both alpha-1 and alpha-2 receptors. Alpha-1 receptor activity has been shown to alter activity in the prefrontal cortex, an area of the brain involved in planning and organization. The authors conducted a double-blind, placebo controlled study with 16 adults with ADHD. Nine of the adults were receiving d-amphetamine and 7 were not. Prazosin used alone was effective in reducing ADHD symptoms. However, when prazosin was given to adults who were also taking dextroamphetamine, there appeared to be a negative interaction, implying that the prazosin actually interfered with the stimulant effect. This study suggests that noradrenergic alpha-1 receptor activity may be important in the pathophysiology of ADHD and the mechanism of action of d-amphetamine medication.


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http://www.nimh.nih.gov/about/advisory-boards-and-groups/namhc/2006/september/director-report.pdf

Blood Pressure Medication Relieves Daytime PTSD Symptoms

Current treatments for post-traumatic stress disorder (PTSD) are reported to be only minimally effective in reducing both nighttime and daytime re-experiencing and intrusion symptoms; many people with PTSD self-medicate with drugs or alcohol. Recent studies have demonstrated that prazosin (Minipress), a generically available alpha-1 adrenergic antagonist, can reduced night time PTSD symptoms.

A new study by Fletcher B. Taylor, of the Veteran
Health Care System and University of Washington, and colleagues suggests that daytime administration of prazosin also may bring relief from anxiety, nervousness, and fear. The results suggest that daytime administration will not interfere with routine daytime tasks and skills, indicating that prazosin may be an effective addition to current treatments. Taylor FB, Lowe K, Thompson C, McFall MM, Peskind ER, Kanter ED, Allison N, Williams J, Martin P, Raskind MADaytime prazosin reduces psychological distress to trauma specific cues in civilian trauma posttraumatic stress disorder. Biol Psychiatry. 2006 Apr 1;59(7):577-81.



Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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