Posted by williamockham on January 3, 2012, at 13:53:11
In reply to Re: Emsam poop out, a new maoi? » williamockham, posted by Erewhonian on January 2, 2012, at 16:08:28
> > so if absorption is linear
>
> Which it probably isn't. It hasn't been studied, to the best of my knowledge, but the drug manufacturer is always careful to say that it doesn't guarantee a release rate. The things I've read about emsam around the web suggest that most of what is going to be absorbed is absorbed in the first 12 hours.Fig 3 in the Emsam PI seems to indicate it's pretty linear, but maybe I'm reading this wrong.
> But I love one mental image that document paints for me, that of a bunch of scientists trying to force subjects to eat 2lbs of cheddar cheese in 30 minutes.
>Hahaha. Oh you don't want any more cheddar? Have some chicken liver that's been lying around a week...
> What you said about multiple patches though, it makes me think again about something other than the insomnia that might have caused the poop out. It was an awfully hot summer here (often got 110+ Fahrenheit), which caused me to sweat off some patches. I sometimes also felt sick when I could feel the patch dumping WAY too much selegiline into me because of the heat. Maybe replacing a patch (or on at least one day I can remember, two) plus all that heat was dumping a lot more of the drug into my system. Maybe enough that I became resistant to normal dosing?
Huh. You know, every time I went up in dose, I'd get insomnia/physical anxiety for a few days. And every so often I'd get it without any dose increase, for a day or two--might be this same phenomena, as it was also during an occasionally scorching summer.>
> I dunno. Just wondering. I started discontinuing the emsam about a week ago. I'm expecting any pdoc I can find to give me an oral maoi would want a two-week washout anyway. Plus I'm hoping a clean slate might help the new drug (hell, I've even read that it might restore the effectiveness of the emsam, but I'm not willing to potentially waste the time testing that out)
>I waited four days after stopping Emsam; pdoc thought that sufficient to get rid of the selegiline and amphetamine metabolites. "No point in waiting for MAO to regenerate if you're just going to wipe it out again."
Nardil 90, Lamictal 175, Seroquel 75
poster:williamockham
thread:1005595
URL: http://www.dr-bob.org/babble/20111226/msgs/1006235.html