lithium 5-ht1b + gsk-3b

Posted by linkadge on December 25, 2011, at 19:54:22

ok, so I think I'm on to something here.
Lithium has been postulated to interact with the 5-ht1b serotonin autoreceptors. In doing some reading, this effect may be due to the interaction of lithium with gsk-3b.
http://www.ncbi.nlm.nih.gov/pubmed/21372171
According to the website above, gsk-3b inhibitors work to desensitize the serotonin 1b autoreceptor. This effect would enhance the activity of serotonin via reuptake inhibition.
Normally, the 5-ht1b autoreceptors inhibit serotonin release in limbic brain regions. Combining an SSRI with lithium (or another gsk-3b inhibitor like omega-3) would theoretically reduce the activity of the 5-ht1b autoreceptors and thus enhance antidepressant action.
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lithium 5-ht1b + gsk-3b linkadge 12/25/11
Re: lithium 5-ht1b + gsk-3b SLS 12/26/11
Re: lithium 5-ht1b + gsk-3b Phillipa 12/26/11
Re: lithium 5-ht1b + gsk-3b SLS 12/26/11
Re: lithium 5-ht1b + gsk-3b » SLS Phillipa 12/26/11
Re: lithium 5-ht1b + gsk-3b » SLS linkadge 12/27/11
Re: lithium 5-ht1b + gsk-3b » SLS linkadge 12/27/11
Re: lithium 5-ht1b + gsk-3b » linkadge SLS 12/27/11

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