Posted by Conundrum on November 2, 2011, at 11:50:09
In reply to Re: Effexor Failure versus Pristiq Success » SLS, posted by Seige on November 2, 2011, at 10:03:29
> I shared my opinions on Pristiq with my pdoc, and he did say he's seen people have success on Pristiq where they didn't with Effexor. I suspect a feeling it largely comes down to the liver enzyme thing.
They also are not identical in action. Effexor has dopamine reuptake which is stronger at higher doses and interacts with opioid receptors.
Pristiq has barely any effect on dopamine reuptake. The DA effects must be part of the parent molecule or some other metabolite. I have no idea what effects it has on opioid receptors. Pristiq also has a more balanced serotonin to norepinephrine ratio than Effexor.
Take into account the liver metabolism vs kidney metabolism and you have a slightly different medication.
Complaints: post-SSRI problems: anhedonia, memory and concentration problems, sexual anhedonia. )
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poster:Conundrum
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URL: http://www.dr-bob.org/babble/20111027/msgs/1001514.html