Posted by floatingbridge on July 16, 2011, at 10:38:24
In reply to Re: Baclofen for sleep? » desolationrower, posted by mtdewcmu on July 16, 2011, at 1:06:32
Thank you for these links. I'm printing them out. There seems to be a big gap where I live between treatment and (not even very radical) research. Sleep, or rather, it's disturbance, is a cornerstone for so many conditions. Good luck!
> >
> > i think its worth a shot. i dn't remember reading specifically on improved sleep structure, but i don't remember negative studies either.
> >
>
> There aren't many studies. Here are a few random ones that I found:
>
> In this one, they gave baclofen to people with mild sleep-disordered breathing and found that they slept longer and got more REM and NREM:
>
> http://www.ersj.org.uk/content/8/2/230.short
>
> Here's one where they gave it to narcoleptic teenagers and found that they slept longer and had more slow wave sleep:
>
> http://www.sciencedirect.com/science/article/pii/S0887899409000824
>
> Here's one where they make reference to GABA-B agonists increasing slow-wave sleep while leaving REM undisturbed.
>
> http://www.ingentaconnect.com/content/adis/cns/2009/00000023/00000008/art00005
>
> Here's one where they found that baclofen helps rats sleep better when they're stressed:
>
> http://www.jstage.jst.go.jp/article/jphs/109/4/109_518/_article
>
> Plus, I have found some studies where they showed that GABA-B is important in sleep architecture.
>
> > diphenhydramine is cheap as sh*t. 2 or 3 bucks should last you half a year.
> >
>
> I have already been through the usual suspects.
poster:floatingbridge
thread:991101
URL: http://www.dr-bob.org/babble/20110714/msgs/991161.html